SPRING BANK PHARMACEUTICALS, INC. Spring Bank Pharmaceuticals, Inc. announced a new clinical collaboration with Roche, to explore the co-administration of SB 11285, Spring Bank's intravenously (IV)-administered STING (STimulator of INterferon Gene) agonist with Roche's PD-L1 checkpoint inhibitor atezolizumab (Tecentriq®) in patients with advanced solid tumors. During the fourth quarter of 2019, Spring Bank dosed the first patient in the monotherapy dose escalation component of the intravenously-administered SB 11285 Phase 1a trial. This monotherapy dose escalation component will be followed by a combination dose escalation of IV SB 11285 with a checkpoint inhibitor (nivolumab) and with atezolizumab (Tecentriq®) as an additional arm added to the combination dose escalation segment of the Phase 1a trial.
By the end of 2020, Spring Bank plans to generate sufficient data from its Phase 1a/1b IV STING agonist program to enable advancement into a Phase 2 clinical trial. As noted above, Phase 1a of the IV SB 11285 Phase 1 trial is a dose-escalation study with monotherapy followed by combination with one or more checkpoint inhibitors and is designed to determine a recommended Phase 2 dose. Phase 1b of the trial will explore IV SB 11285 antitumor activity in combination with a checkpoint inhibitor in selected tumor types.
The trial is being conducted at multiple sites in the United States.
