Spring Bank Pharmaceuticals, Inc. announced that its Phase 1a/1b clinical trial of the company’s intravenously (IV)-administered STING agonist, SB 11285, continues to advance to an escalated monotherapy dosing level and the first cohort in which patients in the trial will receive the co-administration of the IV STING agonist and a checkpoint inhibitor. This Phase 1a/1b trial has been able to progress on track even in the midst of challenges posed by the COVID-19 pandemic. SB 11285 is currently being evaluated as an IV-administered monotherapy in a Phase 1a/1b multicenter, dose escalation clinical trial in patients with advanced solid tumors. The Safety Review Committee for this clinical trial has recommended dose escalation to monotherapy dose level 3 and concurrent opening and dosing of combination dose level 1 with Roche’s PD-L1 checkpoint inhibitor atezolizumab (Tecentriq®). To date, no dose limiting toxicities (DLTs) or drug-related serious adverse events (SAEs) have been observed. Dr. Filip Janku, Associate Professor at MD Anderson Cancer Center, presented a “trial in progress” poster (#226) at the ASCO Virtual Annual Meeting. This poster, which is available on the Publications page of Spring Bank’s website, outlines the IV SB 11285 STING agonist mechanism of action, SB 11285 in vivo data and trial design for the Phase 1a/1b ongoing trial.