On January 28, 2022, RenovaCare, Inc., a Nevada Corporation (the “Company”), entered into a Research and Collaboration Agreement (the “Collaboration Agreement”) with HistoCell S.L., a regenerative medicine company located in Spain (“HistoCell”) (collectively, the “Parties”). Under the Collaboration Agreement, the Parties will collaborate (the “Collaboration”), each contributing its unique experience and technology, on the terms in the Collaboration Agreement, in the development, and if warranted the testing and commercialization of a portable spray device to treat burn and trauma wounds in out-patient clinical and field settings (the “Product”). The purpose of the Collaboration is to develop the Product.

Should the Parties agree that they want to jointly commercialize the Product, the Parties shall then enter into a definitive commercialization agreement setting forth, among other things, the financial terms of the joint commercialization of the Product, and the provisions of any cross licensing of a Party's Solely Owned Research IP. The Collaboration Agreement defines the rights and obligations of the Parties, and includes, among other terms, the following: (a) term of five (5) years. The Collaboration Agreement shall automatically terminate on (i) the fifth (5th) anniversary date of the Effective Date or (ii) the eighteenth (18th) month anniversary of the Effective Date if the Parties, individually or collectively, have not secured third-party funding for the Collaboration.

This Collaboration Agreement may be terminated or extended at any time by mutual written agreement of the Parties. Either Party may also terminate the Collaboration Agreement upon the occurrence by the other Party of, but not limited to, (a) a breach of the Collaboration Agreement, (b) bankruptcy or liquidation, (c) lack of progress or poor performance, (d) merger or consolidation or other corporate transaction, and (e) entry into another R&D collaboration agreement that may be in conflict with the Collaboration Agreement. (b) each of the parties shall be responsible for funding of its portion of the Research.

Funding and budget for the co-development and clinical testing of the Product will be contingent on obtaining the requisite funding; and (c) provisions regarding the ownership of any intellectual property arising from the Research.