On October 12, 2022, Gerald W. Crabtree, the chief scientific officer of PharmaCyte Biotech, Inc. resigned from his position as an employee of the company. In connection with Mr. Crabtree's departure, on October 12, 2022, the company entered into a Release Agreement with Mr. Crabtree. The Release Agreement becomes irrevocable seven days after execution of the Release Agreement and becomes effective on October 20, 2022.