Nautilus Biotechnology, Inc. Partners with the Translational Genomics Research Institute to Investigate Applications of Single-Molecule Proteomic Analysis in Diffuse Intrinsic Pontine Glioma
January 19, 2023 at 08:00 am EST
Share
Nautilus Biotechnology, Inc. and the Translational Genomics Research Institute (TGen) announced a partnership to explore the utility of the Nautilus platform by studying specific protein targets in diffuse intrinsic pontine glioma (DIPG), a rare and often fatal childhood cancer. The goal of the partnership between Nautilus and TGen is to better understand the epigenetic mechanisms at work in DIPG by interrogating the proteoform landscape of specific proteins at the single-molecule level. In doing so, TGen plans to explore the combination of alterations and modifications present on these proteins (proteoforms) that are not possible to detect by peptide-based protein analysis methods.
This collaboration represents the fifth early collaboration program for Nautilus as it advances towards broader platform access in 2023 and commercial launch in 2024. DIPG is a brain tumor that occurs in an area of the brainstem (the pons) which controls many of the body's most vital functions such as breathing, blood pressure, and heart rate. Because of its location in the brain and how rapidly it progresses, DIPG is difficult to treat and is regarded as a high-grade malignant brain tumor.
DIPG is characterized by specific mutations in genes coding for histone proteins. These affected histones then reprogram the epigenome, ultimately leading to cancer.
Nautilus Biotechnology, Inc. is a development stage life sciences company. The Company is engaged in creating a platform technology for quantifying and unlocking the complexity of the human proteome. The Company is focused on transforming the field of proteomics by democratizing access to the proteome and enabling fundamental advancements across human health and medicine. The Company's platform end-to-end solution comprised of the proteome analysis system, consumables, and software. The Companyâs products include Proteome Analysis System, and Reagent Kits. Its proteome analysis system is a high-resolution optical imaging system coupled with integrated fluidics and liquid handling sub-systems. The Companyâs Reagent Kits are comprised of four main components: sample preparation, flow cell(s), multi-affinity probe reagents, and instrument buffers used to perform multi-cycle analysis runs.
Nautilus Biotechnology, Inc. Partners with the Translational Genomics Research Institute to Investigate Applications of Single-Molecule Proteomic Analysis in Diffuse Intrinsic Pontine Glioma