Cocrystal Pharma, Inc. provided an update on the clinical development of its oral first-in-class pan-norovirus and pan-coronavirus dual protease inhibitor CDI-988 and its oral PB2 inhibitor CC-42344 for the treatment of pandemic and seasonal influenza A. CDI-988 and CC-42344 were specifically designed and developed using Cocrystal's unique structure-based drug discovery technology platform to be effective on a broad range of viruses causing these diseases. CDI-988 targets a highly conserved region in the active site of the main 3CL protease required for viral RNA replication for pandemic norovirus and coronaviruses, including SARS-CoV-2. CDI-988 is being evaluated for safety and pharmacokinetics in a randomized, double-blinded, placebo-controlled Phase 1 study in healthy subjects being conducted in Australia. The Company reports favorable preliminary data from the single-ascending dose cohorts of the clinical study.

Cocrystal expects to report topline results from the Phase 1 study this year. CC-42344 binds to a highly conserved PB2 site of the influenza A polymerase complex and exhibits a novel mechanism of action that inhibits viral replication. A randomized, double-blind, placebo-controlled Phase 2a clinical study with CC-42344 is underway in the United Kingdom.

The Company reports favorable tolerability and safety in the first cohort of the Phase 2a influenza A challenge study and expects to report topline Results from the Phase 2a clinical study this year. In 2022 Cocrystal reported favorable safety and tolerability results in the healthy volunteer Phase 1 study with CC-42344 conducted in Australia. Although norovirus is a worldwide public health problem, there are no effective treatments or vaccines.

Norovirus afflicts an estimated 685 million people annually at an estimated societal cost of $60 billion.