Seikagaku : Announces an Academic Conference Presentation on SI-6603 by Licensee Ferring Pharmaceuticals Inc.

April 9, 2024

SEIKAGAKU CORPORATION

(Securities Code: TSE 4548)

Seikagaku Announces an Academic Conference Presentation

on SI-6603 by Licensee Ferring Pharmaceuticals Inc.

This news release has been prepared with reference to the press release announced on April 8, 2024 (local U.S. time) by Ferring Pharmaceuticals Inc., which has a license agreement with Seikagaku. The original press release takes precedence.

The original press release is available at https://ferringusa.com/media/us-press-release/.

Seikagaku Corporation (Tokyo, Japan; "Seikagaku") announced today that Ferring Pharmaceuticals Inc. (Parsippany, NJ; "Ferring") gave an academic conference presentation on three subjects concerning SI-6603 at the 26th Annual Meeting of the American Society of Interventional Pain Physicians (ASIPP), held from April 4 to April 6, 2024 in Dallas, Texas (U.S.A.).

Seikagaku is currently developing SI-6603 (generic name: Condoliase) in the U.S. as an investigational therapy intended to treat radicular leg pain associated with lumbar disc herniation (LDH).

Presentation Summary

• A single intradiscal injection of SI-6603 demonstrated significantly greater improvement in leg pain vs. sham at Week 13 in a registrational Phase 3 clinical trial
• An integrated safety analysis showed SI-6603 was well tolerated and could offer a potential treatment option for pain relief from LDH
• A real-world analysis of current treatments for LDH showed a gap in clinical management and a need for new treatment options

For details, please refer to the press release on the following Ferring website. https://ferringusa.com/media/us-press-release/

Reference Information

<About SI-6603 >

SI-6603, which contains condoliase as its active pharmaceutical ingredient, is an investigational product intended to treat radicular leg pain associated with lumbar disc herniation via a single direct injection into the intervertebral disc. It has the potential benefit of not requiring general anesthesia and being less invasive to patients than surgical treatment.

SI-6603 was developed by Seikagaku. Marketing approval in Japan for SI-6603 was obtained from the Ministry of Health, Labour and Welfare in March 2018, and SI-6603 has been sold as HERNICORE® 1.25 units for intradiscal injection through sales partner Kaken Pharmaceutical Co., Ltd. (Tokyo, Japan) since August 1, 2018.

Ferring Pharmaceuticals is a privately-owned,research-driven, specialty biopharmaceutical group committed to building families and helping people live better lives. In the United States, Ferring is a leader in reproductive medicine and maternal health, and in areas of gastroenterology and orthopaedics. Ferring is at the forefront of innovation in microbiome- based therapeutics and uro-oncologyintravesical gene therapy.

For more information, https://www.ferringusa.com.

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Seikagaku and Ferring entered into a license agreement for SI-6603 in August 2016. Under the license agreement, Ferring has acquired exclusive development and commercialization rights to SI-6603 worldwide, excluding Japan.

For details, please refer to the following press release.

Seikagaku Announces the Conclusion of an Exclusive Worldwide License Agreement (excluding Japan) for SI-6603, a Novel Treatment for Lumbar Disc Herniation

https://www.seikagaku.co.jp/en/news/news-2557126754645424970/main/0/link/20160829_e.pdf

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