On March 16, 2020 (the Effective Date"), Jeff J. Ludwig joined Puma Biotechnology, Inc. as its Chief Commercial Officer. Prior to joining the Company, Mr. Ludwig, age 54, worked as the Vice President Oncology Sales for Astellas Pharma Inc. Pursuant to the terms of a letter agreement between the Company and Mr. Ludwig, Mr. Ludwig will serve as the Company's Chief Commercial Officer on an at-will basis.