nRichDX and OraSure Technologies, Inc., have advanced a commercial collaboration to validate and co-promote their products for researchers developing liquid biopsy applications using first-void urine samples. Notably, first-void urine is enriched in biomarkers suitable for molecular analysis in applications such as sexually-transmitted infections, human papillomavirus, and early stage cancer. The companies' products are highly complementary.

The innovative, patented Colli-Pee®? sample collection and preservation device, made by OraSure's subsidiaryNovosanis, is designed to hygienically collect a consistent, volumetric first-void urine sample, and preserve the cell-free nucleic acid (cfDNA, including circulating cell-free tumor DNA, and cfRNA) with its proprietary UAS™? reagent.

nRichDX's patented Revolution Sample Prep System™? is the only IVD-labeled, cfDNA sample prep system that can process up to 20 mL of urine in a single extraction. Together, the Colli-Pee first-void urine collection device with UAS preservative, combined with the nRichDx Revolution System, a semi-automated cfDNA extraction platform, offers a seamless and efficient workflow for large-scale studies requiring urine sample collection, preservation, handling and extraction for downstream processing.

The companies have jointly presented data for cfDNA and ctDNA yields from first-void urine at last November's Association for Molecular Pathology (AMP) Meeting, as well as codeveloping an Application Note and have plans to present at upcoming industry conferences and in future publications.