LEXARIA BIOSCIENCE CORP.
NASDAQ: LEXX
INVESTOR CONTACT
Phone: 250-765-6424 ext. 202 ir@lexariabioscience.com
DRUG DELIVERY PLATFORM INNOVATOR
DehydraTECH™ is Lexaria's patented drug delivery formulation and processing platform technology which improves the way active pharmaceutical ingredients (APIs) enter the bloodstream through oral delivery. Since 2016, Lexaria has developed and investigated DehydraTECH with a variety of beneficial molecules in oral and topical formats. DehydraTECH has repeatedly demonstrated the ability to increase bio-absorption and has also evidenced an ability to deliver some drugs more effectively across the blood brain barrier, which Lexaria believes to be of particular importance for centrally active compounds. Lexaria operates a licensed in-house research laboratory and holds a robust intellectual property portfolio with 41 patents granted and many patents pending worldwide. For more information, please visit www.lexariabioscience.com.
2024 Investment Highlights
- Hypertension: IND opening study HYPER-H23-1
- GLP-1drugs: Conduct animal and human clinical studies to examine DehydraTECH-processedGLP-1 drugs
DehydraTECH
- Patented formulation and dehydration processing method changes how the body detects and absorbs drugs
- 41 patents granted covering method-of-use,composition-of-matter and medical treatment claims
Patented DehydraTECH Process
1 | Combine Active | Apply to food / carrier | Perform dehydration | Render as powder or liquid for use | ||
Pharmaceutical Ingredient | 2 | particles | 3 synthesis procedure | 4 | in desired final form factor |
with Fatty Acid Oil
DehydraTECH Benefits
Speeds up onset Increases bioavailability Improves drug potency Lower dosage Lower cost
DehydraTECH in Published Papers
For more information visit: Lexaria Research | Journal of Functional Foods - November 2023 |
International Journal of Molecular Sciences - June 2023 | Biomedicine & Pharmacotherapy - June 2023 |
Advances in Therapy - June 2023 | Pharmaceuticals - April 2023 |
Cannabis and Cannabinoid Research - April 2023 | Biomedicine & Pharmacotherapy - April 2023 |
Journal of Personalized Medicine - June 2022 | Advances in Therapy - September 2019 |
PRICE | 52 WK RANGE | AVG. VOLUME | SHARES OUTSTANDING | MARKET CAP | INSIDER OWNERSHIP |
$3.45 | $0.65 - $6.85 | 952,633 | 12.9 M | $41.8 M | 5.0% |
Lexaria Bioscience Corp. - #100-740 McCurdy Road - Kelowna, BC, Canada
www.lexariabioscience.com
LEXARIA BIOSCIENCE CORP.
NASDAQ: LEXX
INVESTOR CONTACT
Phone: 250-765-6424 ext. 202 ir@lexariabioscience.com
DRUG DELIVERY PLATFORM INNOVATOR
DehydraTECH FDA Phase 1b IND Program - Stage 1/2 Hypertension
- Successfulpre-INDmeetingwith the FDA in 2022 with 505(b)(2)NDA regulatory pathway confirmed;
- Received FDA clearancefor IND opening study HYPER-H23-1
- Phase 1b randomized, double-blind,placebo-controlled study of the safety, pharmacokinetics, and pharmacodynamics of DehydraTECH-CBD for the treatment of stage 1 or 2 hypertension
- Only a handful ofother published studieshave investigated resting blood pressure impacts of CBD; none have reported sustained reductions except DehydraTECH-CBD
- FDA has issuedclear guidelinesdefining the need for new antihypertensives that offer novel modes of action
- Treatment of Stage 1 or 2 hypertensive patients not adequately managed with existing treatments
DehydraTECH for Diabetes and Weight Loss
- Randomized, cross-over,single-dose,Investigator-initiated pilot study in 7 healthy volunteers
- Rybelsus® 7mg tablets vs. DehydraTECH-Semaglutide 7 mg compound formulated capsules
- Blood sampled at 18 intervals from T=0 to T=600 min and again at T=24hr post-dose follow up
- Higher blood semaglutide levels / AUC demonstrated throughout the studyduration withDehydraTECH (p<0.05)
- Blood glucose levels lower throughout the study with DehydraTECH (p<0.05); most notably post prandially
- Enhancedcentral deliveryattributes of DehydraTECH contributed to the pronounced GLP-1 effect profile
- Apparent improvements in gastrointestinal tolerability witnessed: Zero instances of moderate nausea/diarrhea with DehydraTECH-Semaglutide; moderate nausea (n=2) and moderate diarrhea (n=1) only reported with Rybelsus® treatment
- Detailed overview of Lexaria's 2024 GLP-1/Diabetes and Weight Loss Study Programs
Blood semaglutide levels | Blood glucose levels | |||||||||||
Rybelsus 7mg (n=7) | DehydraTECH-Semaglutide 7mg (n=7) | Rybelsus 7mg (n=7) | DehydraTECH-Semaglutide 7mg (n=7) | |||||||||
10.0 | 6.0 | |||||||||||
8.0 | 5.5 | |||||||||||
6.0 | 5.0 | |||||||||||
4.5 | ||||||||||||
4.0 | 4.0 | |||||||||||
2.0 | 3.5 | |||||||||||
0.0 | 3.0 | |||||||||||
0 | 100 | 200 | 300 | 400 | 500 | 600 | 700 | 0 | 200 | 400 | 600 | 800 |
Time (min) | Time (min) | |||||||||||
MANAGEMENT |
Chris Bunka, Chairman & CEO
- Launched several successful private and public companies since the late 1980's
- Extensive experience in the capital markets, corporate governance, M&A and finance
- Named inventor on multiple patent innovations
John Docherty, M.Sc., President & Director
- Specialist in development of drug delivery technologies
- Former President and COO of Helix BioPharma Corp. (TSX: HBP)
- Named inventor on multiple issued and pending patents
Lexaria Bioscience Corp. - #100-740 McCurdy Road - Kelowna, BC, Canada
www.lexariabioscience.com
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Lexaria Bioscience Corp. published this content on 11 April 2024 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 11 April 2024 20:32:08 UTC.