Destiny Pharma plc announced the publication of new microbiological data on XF-73 (exeporfinium chloride), its leading antibacterial drug,in Frontiers in Cellular and Infection Microbiology. The paper, 'Screening of the novel antimicrobial drug XF-73 against 2,527 Staphylococcus species clinical isolates',examined the efficacy of XF-73 against more than 2,500 Staphylococcus isolates with wide geographical and clinical diversity. These isolatesfrom 33 countries across Europe, North America, South America, Asia and Africa, encompass 16 different staphylococcal species, including resistant strains taken from patient infections such as skin and soft tissue infections, respiratory tract infections and hospital-acquired pneumonia.

The screening of XF-73 against this wide range of isolatesyielded the following landmark findings: XF-73 effective against all 2,527 isolates tested; XF-73 effective against all tested antibiotic resistance mechanisms; XF-73effective against 840 MRSA1clinical isolates from around the world; XF-73 effective against S. epidermidis, S. saprophyticus, S. haemolyticus, S.capitis, S. hominis and S. lugdunensis - all of high clinical significance. These critical findings support the urgency of XF-73 nasal's late-stage development and need for its global regulatory approval. XF-73 demonstrates exceptionally broad potency across a huge range of Staphylococcus isolates, including antibiotic resistant strains, with no resistance observed.

This study demonstrates XF-73's global effectiveness and reinforces the significant commercial opportunity. Importantly it also demonstrates the potential of XF-73 nasal to address the shortcomings of current standard of care nasal antibiotics, which contribute to the global rise in Staphylococcus aureus antibiotic resistance thereby limiting the effectiveness of current infection reduction approaches.