Oral presentation:
- Title: obecabtagene autoleucel in adult relapsed/refractory B Cell acute lymphoblastic leukemia: Survival and potential impact of CAR-T cell persistence and stem cell transplantation in the FELIX study
Session Title: s419 Acute lymphoblastic leukemia - Clinical 1: Immunotherapy: antibodies and CAR-T cells
Session date and time:Friday, June 14 from14:45 - 16:00 CEST
Session room: N104
Final Abstract Code: S114
Presenting Author: Dr.Claire Roddie
Poster presentations:
- Title: obecabtagene autoleucel (obe-cel, AUTO1) for relapsed/refractory adult B-Cell acute lymphoblastic leukemia (R/R B-ALL): The impact of inotuzumab-containing bridging therapy on treatment outcomes
Session Title: Poster session
Session date and time:Friday, June 14 from18:00 - 19:00 CEST
Final Abstract Code: P418
Presenting Author: Dr.Jae H. Park - Title: Droplet digital PCR and flow cytometry sensitivity for measuring CAR-T cell kinetics in adult patients with relapsed/refractory B Cell acute lymphoblastic leukemia treated with obecabtagene autoleucel
Session Title: Poster session
Session date and time:Friday, June 14 from18:00 - 19:00 CEST
Final Abstract Code: P1469
Presenting Author: Dr.Claire Roddie
About
About obe-cel (AUTO1)
Obe-cel is a CD19 CAR T cell investigational therapy designed to overcome the limitations in clinical activity and safety compared to current CD19 CAR T cell therapies. Obe-cel is designed with a fast target binding off-rate to minimize excessive activation of the programmed T cells. In clinical trials of obe-cel, this “fast off-rate” profile reduced toxicity and T cell exhaustion, resulting in improved persistence and leading to high levels of durable remissions in r/r Adult ALL patients. The results of the FELIX trial, a pivotal trial for adult ALL, have been submitted and accepted by the FDA with a PDUFA target action date of
About obe-cel FELIX clinical trial
Autolus’ Phase 1b/2 clinical trial of obe-cel enrolled adult patients with relapsed / refractory B-precursor ALL. The trial had a Phase 1b component prior to proceeding to the single arm, Phase 2 clinical trial. The primary endpoint was overall response rate, and the secondary endpoints included duration of response, MRD negative CR rate and safety. The trial enrolled over 100 patients across 30 of the leading academic and non-academic centers in the United States, United Kingdom and Europe. [NCT04404660]
Contact:
+44 (0) 7780 471 568
o.manser@autolus.com
+44 (0) 7818 430877
j.wilson@autolus.com
+1-917-513-5303
susan@sanoonan.com
Source:
2024 GlobeNewswire, Inc., source