Scalable and precise DNA size selection following EDTA tube usage offers a cost-efficient alternative to the use of more expensive blood collection tubes (BCTs) and improves next-generation sequencing (NGS) workflows, reducing the risk of failed screening tests for expectant mothers. The data is currently being presented at the 27th
The collaborative study with
Many NIPT clinics and hospitals take a maternal blood sample with an expensive BCT, such as a Streck tube, and the sample is stable for up to 14 days. However, the data presented has shown the capability to use EDTA tubes, which are commonly used and a significantly lower cost, with proven stability up to 7 days.
Sample stability and handling are crucial elements in the preservation of acceptable levels of fetal fraction and ultimately, the successful use of NIPT. Cell lysis due to sample instability can result in the release of maternal genomic DNA, which dilutes the fetal-derived cfDNA, thereby reducing the fetal fraction. The results of the study demonstrate that size selection can be used to recover the fetal fraction from whole blood stored in EDTA tubes over a prolonged period that exceeds the previous limit of 8 hours.
Dr
Visit the poster (programme ID P-94) titled 'A study to demonstrate that prolonged storage of blood in EDTA tubes is compatible with NIPT when using size selection to enrich fetal fraction' presented at ISPD taking place from 18-21 June. Copies of the poster will also be available to download from Yourgene's website: https://yourgenehealth.com/our-products/instruments/lightbench-detect/pac_dtm_child_2
Contact:
Dr
Tel: +44 7789 053885
Email: michelle.ricketts@codoncommunications.com
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