Shire : Jeff Poulton Appointed Shire Chief Financial Officer

Jeff Poulton Appointed Shire Chief Financial Officer and Joins Board of Directors

Dublin, Ireland- April 30, 2015 - Shire plc (LSE: SHP, NASDAQ: SHPG) announces
the appointment of Jeff Poulton as Chief Financial Officer (CFO) and member of
the Executive Committee. Jeff will additionally join the Shire Board of
Directors. Both appointments are effective immediately.

Jeff has served as Interim CFO since December 2014, while overseeing Investor
Relations. As CFO, he will remain based in Lexington. An experienced
pharmaceuticals and biotechnology executive, Jeff has extensive experience
across financial, commercial and strategic leadership roles. He joined Shire in
2003.

Shire CEO Flemming Ornskov said: "Jeff brings demonstrated leadership
capabilities across all elements of the finance organization as well as deep
knowledge of the Shire business and effective relationships with the investment
community and other stakeholders. We are pleased he will continue to provide
leadership as we deliver our growth plan and drive operational excellence and
efficiency that will help us to become a world-leading biotech focused on the
unmet needs in rare diseases and other specialty conditions."

Shire Chairman of the Board of Directors Susan Kilsby commented: "Jeff will
join the Shire Board of Directors at a time when the company is building for
the future. We have conducted an extensive search of both internal and external
candidates. Jeff's expertise and extensive knowledge of Shire's business and
markets set him apart as CFO and will further strengthen the Shire board as it
oversees the company's transformation."

Jeff's experience at Shire includes leading the Global Rare Diseases business
unit, and overseeing the integration of Viropharma's rare diseases products
into the Shire portfolio. Previously, Jeff served in diverse corporate finance
and business development roles for Cinergy Corp. and PPG Industries. Jeff
served as a commissioned officer in the United States Navy, and has a B.A. in
economics from Duke University and a MBA in Finance from the Kelly School of
Business at Indiana University.

For further information please contact:

Investor Relations                                                             
                                                                               
Sarah Elton-Farr                        [e-mail] [phone]   
                                                                               
Media                                                                          
                                                                               
Michele Galen                           [e-mail]     [phone]   
                                                                               
Brooke Clarke                           [e-mail]    [phone]   


NOTES TO EDITORS

Shire enables people with life-altering conditions to lead better lives.

Our strategy is to focus on developing and marketing innovative specialty
medicines to meet significant unmet patient needs.

We focus on providing treatments in Rare Diseases, Neuroscience,
Gastrointestinal and Internal Medicine and we are developing treatments for
symptomatic conditions treated by specialist physicians in other targeted
therapeutic areas, such as Ophthalmics.

www.shire.com

There is no information required to be disclosed in respect of Jeff Poulton
under Listing Rules 9.6.13.R.

                                                                             
Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX

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