On March 19, 2019, Niall Murphy ceased serving as the Vice President and Corporate Controller of Protagonist Therapeutics, Inc. (the “Company”), including in his capacity as Interim Principal Accounting Officer. Following Mr. Murphy’s departure, Dinesh V. Patel, Ph.D., the Company’s President and Chief Executive Officer, was appointed to serve as the Company’s Interim Principal Accounting Officer, effective as of March 20, 2019. Dr. Patel will also continue to serve as the Company’s Interim Principal Financial Officer. Dr. Patel has served as a member of the Company’s board of directors and as the Company’s President and Chief Executive Officer since December 2008.