On March 14, 2021, Robert M. Whelan, Jr., a member of the Board of Directors of the Annovis Bio, Inc., the Chairman of the Audit Committee and a member of the Compensation Committee and the Nominating and Corporate Governance Committee, notified the Company of his retirement and resignation from the Company's Board of Directors and each committee thereof, effective as of the date of his notice. Mr. Whelan did not resign as a result of any disagreement with the Company on any matter relating to its operations, policies or practices. Effective March 15, 2021, Mark White, a member of the Company's Board of Directors, has been appointed to serve to as the Chairman of the Audit Committee, (2) Mr. White has also been appointed to serve as a member of the Compensation Committee, and (3) Claudine Bruck, a member of the Company’s Board of Directors, has been appointed to serve as a member of and the Chairman of the Nominating and Corporate Governance Committee.