- Preliminary LUNA data presented at the Annual Meeting of the
- Completed
- Cash runway expected into late 2025 –
- 1-for-10 reverse stock split to be effective
“We have made tremendous progress during 2023 and in 2024 to date in our development of Ixo-vec as a durable potential gene therapy treatment for the millions of patients suffering from wet AMD,” stated
Ixo-Vec Program Highlights:
- Preliminary Ixo-vec LUNA Trial Data at
Macula Society 2024:- In
February 2024 , we announced positive preliminary efficacy and safety data from the ongoing LUNA Phase 2 trial of Ixo-vec in patients with wet AMD at the 47th Annual Meeting of theMacula Society inPalm Springs, California . - LUNA patients treated with either the 2E11 or 6E10 dose of Ixo-vec experienced potentially best-in-class reduction in annualized anti-vascular endothelial growth factor (VEGF) injections and the percentage of patients receiving no supplemental injections through 26 weeks.
- Patients at the 2E11 and 6E10 doses had mean 90% and 94% reductions, respectively, in annualized anti-VEGF injections.
- 85% and 68% of patients at the 2E11 and 6E10 doses, respectively, received no supplemental injections through 26 weeks.
- Maintained or improved mean BCVA and mean CST at both dose levels.
- Ixo-vec continued to be generally well tolerated, with cases of intraocular inflammation responsive to local corticosteroids.
- No Ixo-vec related serious adverse events, episcleritis, vasculitis, retinitis, choroiditis, vascular occlusion or hypotony were reported.
- In
- Long-Term Ixo-vec OPTIC Trial Data at AAO 2023:
- In
November 2023 , the company announced 3-year data from the OPTIC extension study of patients with wet AMD during the Retina Subspecialty Day at theAmerican Academy of Ophthalmology (AAO) 2023 Annual Meeting inSan Francisco, California . - Patients in the OPTIC extension trial continue to experience long-term benefit from Ixo-vec through 3 years of follow-up, including maintenance of vision, durability of anatomic improvements and sustained reduction in anti-VEGF treatment burden.
- Patients at the 2E11 dose had an 84% reduction in annualized anti-VEGF injections, with 53% of the participants at the 2E11 dose receiving zero supplemental injections through three years.
- Aflibercept protein levels have been sustained through follow-up, which is up to 4.5 years post-treatment.
- BCVA was maintained and CST was improved through 3 years.
- Ixo-vec was generally well tolerated, with the most common adverse event being dose-dependent inflammation that was responsive to topical corticosteroids.
- In
Corporate Updates:
- Approval of 1-for-10 reverse stock split: On
March 8 , the Board of Directors approved a 1-for-10 reverse stock split of the Company’s common stock. The Company's common stock will begin trading on a reverse stock split-adjusted basis onMarch 21, 2024 . Following the reverse stock split, there will be approximately 20.8 million shares of the company’s common stock outstanding. $127.5 Million Private Placement Financing: InFebruary 2024 , the Company completed a private placement of 106.25 million shares of common stock (or pre-funded warrants in lieu thereof) to a select group of institutional and accredited healthcare specialist investors at a price of$1.20 per share, representing a premium of approximately 20% to Adverum’s 30-day volume-weighted average price. The financing was led by TCGX with participation from new and existing investors including5AM Ventures,Commodore Capital , Frazier Life Sciences,Logos Capital , Samsara BioCapital,Venrock Healthcare Capital Partners and Vivo Capital , as well as two large investment management firms. The financing is expected to extend Adverum’s cash runway into late 2025.- Appointment of Romuald Corbau, Ph.D. as Chief Scientific Officer: In
January 2024 , the company announced the appointment of Romuald “Romu” Corbau, Ph.D. as Chief Scientific Officer. Dr. Corbau brings over 25 years of experience in drug development, including leading Spark Therapeutics’ translational R&D for Luxturna®, a subretinal injection gene therapy product for Leber’s congenital amaurosis, an inherited vision loss disease that routinely results in blindness
Anticipated Milestones
- 2024: Continued FDA and EMA formal and informal regulatory interactions
- Mid-2024: LUNA 26-week interim analysis
- H1 2025: Initiation of Phase 3 trial
Financial Results for the Three Months Ended
- Cash, cash equivalents and short-term investments were
$96.5 million as ofDecember 31, 2023 , compared to$117.1 million as ofSeptember 30, 2023 , and$185.6 million as ofDecember 31, 2022 . Including proceeds from theFebruary 2024 private placement financing, pro forma cash, cash equivalents and short-term investments was$223.8 million . Adverum expects its cash, cash equivalents and short-term investments to fund operations into late 2025. - Research and development expenses were
$15.3 million for the three months endedDecember 31, 2023 , compared to$22.2 million for the same period in 2022. Research and development expenses decreased due to lower clinical trial related expense, lower material production and bioanalytics, lower stock-based compensation expense, lower license fees, and lower outside research and development services. Stock-based compensation expense included in research and development expenses was$1 .0 million for the fourth quarter of 2023. - General and administrative expenses were
$10.9 million for the three months endedDecember 31, 2023 , compared to$11.7 million for the same period in 2022. General and administrative expenses decreased due to lower facilities expense due to fewer premises leased in the current period and higher sublease income and lower depreciation expense. Stock-based compensation expense included in general and administrative expenses was$3.1 million for the fourth quarter of 2023. - Net Loss was
$23.7 million , or$0.23 per basic and diluted share, for the three months endedDecember 31, 2023 , compared to$32.7 million , or$0.33 per basic and diluted share for the same period in 2022.
About Wet Age-Related Macular Degeneration
Wet AMD, also known as neovascular AMD or nAMD, is a VEGF driven advanced form of AMD affecting approximately 10% of patients living with AMD associated with the build-up of fluid in the macula and the retina. Wet AMD is a leading cause of blindness in people over 65 years of age, with approximately 20 million individuals worldwide living with this condition. New cases of wet AMD are expected to grow significantly worldwide as populations age. AMD is expected to impact 288 million people worldwide by 2040, with wet AMD accounting for approximately 10% of those cases. Additionally, wet AMD is a bilateral disease, and incidence of nAMD in the second eye is up to 42% in the first two to three years. The current standard of care requires frequent life-long repeated bolus injections of anti-VEGF in the eye. IVT gene therapy has the promise to preserve vision and reduce most or all injections for the life of the patient by delivering stable therapeutic levels of anti-VEGF to control macular fluid.
About Ixo-vec in Wet AMD
Adverum is developing ixoberogene soroparvovec (Ixo-vec, formerly referred to as ADVM-022), its clinical-stage gene therapy product candidate, for the treatment of wet AMD. Ixo-vec utilizes a proprietary vector capsid, AAV.7m8, carrying an aflibercept coding sequence under the control of a proprietary expression cassette. Unlike other ophthalmic gene therapies that require surgery to administer the gene therapy under the retina (sub-retinal approach), Ixo-vec is designed to be administered as a one-time IVT injection in the physician’s office, deliver long-term efficacy, reduce the burden of frequent anti-vascular endothelial growth factor (VEGF) injections, optimize patient compliance and improve vision outcomes for patients with wet AMD. In recognition of the need for new treatment options for wet AMD, the
About
Forward-looking Statements
Statements contained in this press release regarding events or results that may occur in the future are “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. Such statements include, but are not limited to, statements regarding the potential benefits of Ixo-vec as a one-time IVT injection for the treatment of wet AMD, including its potential to improve vision outcomes, the potential best-in-class clinical activity of Ixo-vec, and anticipated timing of preliminary and interim data from the Phase 2 LUNA trial and initiation of a Phase 3 trial, and statements associated with the Company’s cash sufficiency and runway, and other statements containing the words “anticipates,” “believes,” “expects,” “intends,” “plans,” “target,” “will” and similar expressions. Actual results could differ materially from those anticipated in such forward-looking statements as a result of various risks and uncertainties, including risks inherent to, without limitation: risks associated with market conditions. Additional risks and uncertainties facing Adverum are set forth under the caption “Risk Factors” and elsewhere in Adverum’s
Corporate, Investor and Media Inquiries
E: ir@adverum.com
Selected Consolidated Balance Sheet Data | ||||||
(In thousands) | ||||||
2023 | 2022 | |||||
Cash and cash equivalents, and marketable securities | $ | 96,526 | 1 | $ | 185,589 | |
Total assets | 173,010 | 308,372 | ||||
Total current liabilities | 24,914 | 32,246 | ||||
Total liabilities | 89,541 | 126,854 | ||||
Total stockholders' equity | 83,469 | 181,518 | ||||
(1) Cash, cash equivalents, and marketable securities exclude approximately | ||||||
Consolidated Statements of Operations | |||||||||||||||
(In thousands except per share data) | |||||||||||||||
Three months ended | Years ended | ||||||||||||||
2023 | 2022 | 2023 | 2022 | ||||||||||||
(Unaudited) | (1) | ||||||||||||||
License revenue | $ | — | $ | — | $ | 3,600 | $ | — | |||||||
Operating expenses: | |||||||||||||||
Research and development | 15,278 | 22,199 | 77,676 | 99,277 | |||||||||||
General and administrative | 10,880 | 11,741 | 49,915 | 57,858 | |||||||||||
Total operating expenses | 26,158 | 33,940 | 127,591 | 157,135 | |||||||||||
Operating loss | (26,158 | ) | (33,940 | ) | (123,991 | ) | (157,135 | ) | |||||||
Other income, net | 1,311 | 1,223 | 5,748 | 2,673 | |||||||||||
Net loss before income taxes | (24,847 | ) | (32,717 | ) | (118,243 | ) | (154,462 | ) | |||||||
Income tax benefit (provision) | 1,133 | (19 | ) | 1,078 | (74 | ) | |||||||||
Net loss | (23,714 | ) | (32,736 | ) | (117,165 | ) | (154,536 | ) | |||||||
Net loss per share — basic and diluted | $ | (0.23 | ) | $ | (0.33 | ) | $ | (1.16 | ) | $ | (1.56 | ) | |||
Weighted-average common shares outstanding - basic and diluted | 101,213 | 99,915 | 100,824 | 99,251 | |||||||||||
(1) Derived from Adverum's annual audited consolidated financial statements. |
Source:
2024 GlobeNewswire, Inc., source