"The guilt of former executives of Orange was upheld on appeal," the court said in a statement.
The workers' deaths during a restructuring at the company in the late 2000s led to deep soul-searching over corporate culture in France.
Orange had also been found guilty of the same "moral harassment" charge during the December 2019 ruling, and fined 75,000 euros ($73,733), but the company had then said it would not appeal.
Many individual managers have been convicted of harassment, and often fired as a result, but not companies themselves.
($1 = 1.0172 euros)
(Reporting by Benoit Van Overstraeten; editing by Dominique Vidalon and Jason Neely)
