- Phase II dose-finding trial met primary endpoint after 46 weeks of treatment, representing an important advancement of Boehringer Ingelheim’s cardio-renal-metabolic focus areas
- Full data will be presented at the 2023 American Diabetes Association’s 83rd Scientific Sessions
- Novel dual glucagon/GLP-1 receptor agonist BI 456906 is part of the collaboration between
Boehringer Ingelheim andZealand Pharma
Ingelheim,
“Obesity is one of many cardio-renal-metabolic diseases, which together represent one of the fastest growing health challenges worldwide. The distinct mode of action of BI 456906 targets multiple pathways pivotal to metabolic regulation, including those associated with obesity and liver diseases,” said Carinne Brouillon, Head of Human Pharma,
“We are both enthusiastic about these data and encouraged by the clinical outcomes announced today,” said
In 2016, more than 1 billion people worldwide were living with cardio-renal-metabolic (CRM) diseases such as obesity, type 2 diabetes, chronic kidney disease, liver disease, heart failure and cardiovascular disease1-10. Obesity is a major global health challenge, and the worldwide prevalence has more than doubled over the past four decades11.
Notes to editors
About the study
This is a Phase II, randomized, parallel group, dose-finding study of subcutaneously administered BI 456906 for 46 weeks compared to placebo in people living with overweight or obesity. The trial included 20 weeks of dosing escalation and 26 weeks maintenance.
About BI 456906
The glucagon/GLP-1 receptor dual agonist activates both the GLP-1 and glucagon receptors that are critical to controlling metabolic functions. The dual agonist BI 456906 has the potential to be a new treatment that may offer clinically relevant benefit. It is part of Boehringer Ingelheim’s research and development portfolio in the cardio-renal-metabolic disease areas.
BI 456906 was co-invented by
About
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This press release is issued from our Corporate Headquarters in Ingelheim,
About Zealand Pharma A/S
Zealand was founded in 1998 and is headquartered in
Forward-Looking Statement
The above information contains forward-looking statements that provide Zealand Pharma’s expectations or forecasts of future events. Such forward-looking statements are subject to risks, uncertainties and inaccurate assumptions, which may cause actual results to differ materially from expectations set forth herein and may cause any or all of such forward-looking statements to be incorrect. If any or all of such forward-looking statements prove to be incorrect, our actual results could differ materially and adversely from those anticipated or implied by such statements. All such forward-looking statements speak only as of the date of this release and are based on information available to
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Email: harro.ten_wolde@boehringer-ingelheim.com
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Email: ank@zealandpharma.com
1. Jager KJ, et al. A single number for advocacy and communication-worldwide more than 850 million individuals have kidney diseases. Kidney Int 2019;96:1048–1050.
2. GBD 2016 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: A systematic analysis for the Global Burden of Disease Study 2016.
3. GBD 2019 Diseases and Injuries Collaborators. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: A systematic analysis for the Global Burden of Disease Study 2019.
4.
5. Alicic RZ, Rooney MT, & Tuttle KR. Diabetic kidney disease: Challenges, progress, and possibilities. Clin J Am Soc Nephrol 2017;12:2032–2045.
6. Roth GA, et al. Global burden of cardiovascular diseases and risk factors, 1990–2019: Update from the GBD 2019 Study. J Am Coll Cardiol 2020;76:2982–3021.
7. Shetty A & Syn WK. Health and economic burden of nonalcoholic fatty liver disease in
8. Mantovani A, et al. Complications, morbidity and mortality of nonalcoholic fatty liver disease. Metabolism 2020;111S:154170.
9. Sidney S, et al. Recent trends in cardiovascular mortality in
10.
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