'We continue to make considerable progress across our pipeline, and we are particularly excited to announce updated Phase Ib efficacy and safety data on RVU120 in patients with relapsed/refractory (R/R) acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (HR-MDS) and preclinical data on SEL24 (MEN1703) at this year's ASH Meeting,' said Pawel Przewiezlikowski, Chief Executive Officer of Ryvu. 'To date, RVU120 showed a complete response and disease stabilizations in 10 patients with r/r AML and HR-MDS. We also recently presented data from a Phase I/II dose-escalation study in advanced solid tumors demonstrating RVU120 therapeutic benefit in the form of disease stabilizations. We are pleased with RVU120's efficacy across hematologic diseases and solid tumors, and we believe RVU120 has the potential clinical utility to improve outcomes for cancer patients.'
THIRD QUARTER 2022 AND RECENT HIGHLIGHTS
Updated Clinical and Preclinical Data on RVU120 at the EORTC-NCI-AACR Molecular Targets and Cancer Therapeutics Symposium: Updated data from the ongoing dose-escalation Phase I/II trial in relapsed/refractory metastatic or advanced solid tumors showed four disease stabilizations in a heavily pre-treated patient group, with three of those lasting more than 4 months. RVU120 was safe and well-tolerated, and the data support the continuation of dose escalation.
Additionally, data from preclinical studies were presented showing that RVU120 enhances the efficacy of ADCC-promoting drugs in-vivo and in-vitro. The combination therapy resulted in complete tumor regressions in preclinical models.
Lastly, preclinical data of proprietary MTA-cooperative PRMT5 inhibitors were presented. These inhibitors selectively target MTAP deficiency, which occurs in 10-15% of all tumors, and demonstrated antitumor efficacy and target engagement in-vivo.
UPCOMING CLINICAL AND CORPORATE MILESTONES
RVU120
Safety and efficacy data from the ongoing Phase Ib clinical study in acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (HR-MDS) will be presented at the 2022
On-target activity of RVU120 in AML and HR-MDS patient samples will also be presented at ASH. As of the cut-off date, inhibition of pSTAT5 reached >50%, a threshold that based on preclinical predictions is sufficient for robust efficacy in certain groups of super-responder patients.
Synthetic lethality
Novel targets identification
SEL24 (MEN1703)
Ryvu's partner
THIRD QUARTER 2022 FINANCIAL RESULTS
Cash Position - On
Operating costs, excluding the non-cash cost of valuation of the Incentive Program (
Net Loss Attributable to Common Shareholders - Net loss attributable to common shareholders excluding the non-cash cost of valuation of the Incentive Program was
About
Ryvu's most advanced programs are RVU120 - a selective CDK8/CDK19 kinase inhibitor with potential for the treatment of hematological malignancies and solid tumors currently in phase I clinical development for the treatment of acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (HR-MDS), and phase I/II for the treatment of r/r metastatic or advanced solid tumors - and SEL24 (MEN1703), a dual PIM/FLT3 kinase inhibitor licensed to the
The company was founded in 2007 and is headquartered in
Contact:
Tel: +1 917-355-2395
Email: jfraunces@lifesciadvisors.com
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