Pain has many faces: from the occasional headache to acute pain caused by sports or accidents, to a chronic condition or one associated with a disease. Until a few years ago, pain patients were mostly treated conventionally. That is, with special devices, over-the-counter drugs such as paracetamol, ibuprofen and Voltaren, or with strong opioid analgesics such as fentanyl, buprenorphine, alfentanil or hydromorphone. However, the latter in particular, are usually not suitable for long-term use due to their risks and side effects.
For this reason, it is extremely positive that cannabis and cannabinoids have been increasingly used in pain therapy for some years now as drugs with relatively few side effects. In this context, the Canadian-Israeli company
Chronic Pain: a Billion-Dollar Market
In particular, patients who refuse or can no longer tolerate common pain medications, or for whom pain medications no longer work, could benefit from CBD therapy. These include, for example, patients with: Osteoarthritis, diabetes mellitus, Fibromyalgia, Rheumatism (rheumatoid arthritis), Back problems, and more.Since pain can be an unpleasant to agonizing "side effect" of many diseases, the global market for painkillers is enormous and is expected to grow in the coming years due to demographic change.
The global analgesics market reached a value of almost
Traditional Analgesics Market Struggles with Restrictions
The projected growth is mainly based on the aging population worldwide, as disease incidence increases with age. At the same time, the market for opioid painkillers is increasingly restricted by legislation. In the
Injectable CBD as a "Gamechanger" in Pain Management
The aforementioned restrictions, combined with projected high market growth, could play into the hands of cannabis active ingredients in the context of pain management. After all, in addition to THC, which is available by prescription, the hemp plant contains a total of over 100 active ingredients. Of medical interest and now the focus of research is therefore also cannabidiol (CBD), which, unlike THC, does not act via opioid receptors and is therefore unlikely to be addictive or intoxicating.
Cannabis or CBD have advantages that other active ingredients do not: The body itself produces very similar substances - the so-called endocannabinoids. They exert their effect via various receptors that are also receptive to ingested cannabis active ingredients. The CB1 receptor is found in the central nervous system and many other organs. It relieves anxiety, stress, restlessness and: pain.
However, since CBD is usually administered orally or locally, a problem arises: bioavailability is greatly reduced by the "detour" via the liver and the digestive tract.
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