Half-Year 2020
Financial
Results &
Second Quarter
Business
Update
July 30, 2020
Forward-Looking Statements
!
This presentation has been prepared by argenx se ("argenx" or the "company") for informational purposes only and not for any other purpose. Nothing contained in this presentation is, or should be construed as, a recommendation, promise or representation by the presenter or the company or any director, employee, agent, or adviser of the company. This presentation does not purport to be all-inclusive or to contain all of the information you may desire. This presentation also contains estimates and other statistical data made by independent parties and by us relating to market size and growth and other data about our industry. This data involves a number of assumptions and limitations, and you are cautioned not to give undue weight to such estimates.
Safe Harbor: Certain statements contained in this presentation, other than present and historical facts and conditions independently verifiable at the date hereof, may constitute forward-looking statements. Examples of such forward-looking statements include those regarding our investigational product candidates and preclinical studies and clinical trials, and the status, plans, timing of expected data readouts and related presentations and related results thereof, including the design of our trials and the availability of data from them, the timing and achievement of our product candidate development activities, our ability to obtain regulatory approval of our product candidates, the expected size of the markets for our product candidates, future results of operations and financial positions, including potential milestones, business strategy, plans and our objectives for future operations. When used in this presentation, the words "anticipate," "believe," "can," "could," "estimate," "expect," "intend," "is designed to," "may," "might," "will," "plan," "potential," "predict," "objective," "should," or the negative of these and similar expressions identify forward-looking statements. Such statements, based as they are on the current analysis and expectations of management, inherently involve numerous risks and uncertainties, known and unknown, many of which are beyond the Company's control. Such risks include, but are not limited to: the impact of general economic conditions, general conditions in the biopharmaceutical industries, changes in the global and regional regulatory environments in the jurisdictions in which the Company does or plans to do business, market volatility, fluctuations in costs and changes to the competitive environment. Consequently, actual future results may differ materially from the anticipated
results expressed in the forward-looking statements. In the case of forward-looking statements regarding investigational product candidates and continuing further development efforts, specific risks which could cause actual results to differ materially from the Company's current analysis and expectations include: failure to demonstrate the safety, tolerability and efficacy of our product candidates; final and quality controlled verification of data and the related analyses; the expense and uncertainty of obtaining regulatory approval, including from the U.S. Food and Drug Administration and European Medicines Agency; the possibility of having to conduct additional clinical trials; our ability to obtain and maintain intellectual property protection for our product candidates; and our reliance on third parties such as our licensors and collaboration partners regarding our suite of technologies and product candidates. Further, even if regulatory approval is obtained, biopharmaceutical products are generally subject to stringent on-going governmental regulation, challenges in gaining market acceptance and competition. These statements are also subject to a number of material risks and uncertainties that are described in the Company's filings with the U.S. Securities and Exchange Commission ("SEC"), including in argenx's most recent annual report on Form 20-F filed with the SEC as well as subsequent filings and reports filed by argenx with the SEC. The reader should not place undue reliance on any forward-looking statements included in this presentation. These statements speak only as of the date made and the Company is under no obligation and disavows any obligation to update or revise such statements as a result of any event, circumstances or otherwise, unless required by applicable legislation.
2
Agenda for today
1 | Recent Highlights, Including Phase 3 ADAPT Data | ||||
2 | Efgartigimod: Additional Indications | ||||
3 | Cusatuzumab and Early Stage Pipeline | ||||
4 | Launch Preparation | ||||
5 | Financial Results | ||||
6 | Q&A | ||||
3
Recent Achievements in COVID-19 Environment
- Positive topline readout of Phase 3 ADAPT trial
- Financing to support first commercial launch and advancement of pipeline
- BLA filing remains on track
- Opened new trial sites in ITP and CIDP programs
- Prepared for start of Phase 1 healthy volunteer trial of ARGX-117; enabled complement inhibitor to be studied in COVID patients
- Advanced discovery efforts, including work on ARGX-118 and ARGX-119
- Accelerated transformation into a commercial organization with key hires
Advancing Towards 'argenx 2021' Vision
Commercial franchises
argenx 2021: Reaching patients
Global expansion across three locations
Positive Phase 3 ADAPT data
Late-stage pipeline
FcRn leadership | MG | CIDP | ITP | PV |
Cusatuzumab strategic alliance
Immunology breakthroughs | Immunology Innovation Program |
Strong balance sheet | Pro-forma cash position of $2.1B |
5
Efgartigimod Showed Robust Benefit For Patients With gMG
Primary endpoint met
Meaningful patient
benefit observed
Favorable tolerability
observed
- Statistically significant and clinically meaningful improvement in MG-ADL
- Fast and deep responses
- Potential for individualized dosing
- Safety & tolerability profile comparable to placebo
6
ADAPT Data Show Statistically Significant and Clinically Meaningful Improvement in MG-ADL and QMG
7
ADAPT Data Show Fast, Deep and Durable Responses
Minimal Symptom Expression | Fast Onset of Action | Durable Clinical Benefit | ||||||||||
40% of efgartigimod patients achieved minimal | Of the 44 patients who were efgartigimod | Potential for individualized dosing | ||||||||||
symptom Expression compared to 11% in | responders, 84.1% had a fast response initiated | |||||||||||
Placebo | within the first two weeks | |||||||||||
Duration of response | ||||||||||||
(AChR Ab+ Efgartigimod responders, first cycle) | ||||||||||||
max response: | 25 weeks | |||||||||||
12 weeks or more | 34.1% | |||||||||||
8 weeks or more | 56.8% | |||||||||||
6 weeks or more | 88.6% | |||||||||||
4 weeks or more | 100.0% | |||||||||||
0% | 20% | 40% | 60% | 80% | 100% | |||||||
Responder by definition is at least 4 consecutive weeks | ||||||||||||
8
Repeat Treatment Yielded Equally Strong Benefit
MG-ADL responders | MG-ADL responders |
(AChR-Ab+ patients, first cycle) | 27% of | (AChR-Ab+,second cycle) | 36.8% of | ||||||
P < 0.0001 | |||||||||
80% | P < 0.0001 | Efgartigimod patients | 80% | Efgartigimod patients | |||||
70.6% | |||||||||
67.7% | who responded in the | not responding to 1st | |||||||
70% | 1st treatment cycle | 70% | treatment cycle did | ||||||
responders | and never required a | response | respond in 2nd | ||||||
60% | 2nd treatment cycle | 60% | treatment cycle | ||||||
ADL- | 50% | ADL- | 50% | ||||||
40% | 40% | ||||||||
MG | 30% | 29.7% | MG | 30% | 25.6% | ||||
% | % | ||||||||
20% | 20% | ||||||||
10% | 10% | ||||||||
0% | N=44/65 | N=19/64 | 0% | N=36/51 | N=11/43 | ||||
Efgartigimod | Placebo | Efgartigimod | Placebo | ||||||
MG-ADL responder: ≥ 2-point improvement for at least four consecutive weeks during the first cycle | 9 | ||||||||
Developing Highly Differentiated Pipeline | |||||||||
Positive topline ADAPT data | |||||||||
Program | Target | Indication | Preclinical | Phase 1 | Phase 2 | Phase 3 | Registration | Partner | |
IV | FcRn | MG | BLA | ||||||
Efgartigimod | SC Bridging | MG | Bridging | ||||||
IV | PV | ||||||||
IV | ITP | ||||||||
IV + SC | ITP | ||||||||
IV | ITP | ||||||||
SC | CIDP | ||||||||
TBD | 5th indication |
Cusatuzumab
+ AZA | CD70 | Newly diag. AML (unfit) | ||||||
CULMINATE | ||||||||
+ AZA + VEN | Newly diag. AML (unfit) ELEVATE | |||||||
+ AZA | High-risk MDS | |||||||
ARGX-117 | C2 | Autoimmune (MMN) | ||||||
COVID-19 | Neuro- | |||||||
Hem/Onc | Skin | |||||||
ARGX-118 | Galectin 10 | Airway Inflammation | muscular | |||||
ARGX-119 | TBD | TBD | ||||||
MG: Myasthenia gravis ITP: Immune thrombocytopenia PV: Pemphigus vulgaris CIDP: Chronic inflammatory demyelinating polyneuropathy AML: Acute myeloid leukemia MDS: Myelodysplastic syndromes | 10 |
Navigating The Impact Of COVID-19
Telehealth and remote monitoring
Home infusion
SC efgartigimod
133 patients remain on ADAPT+
ADVANCE enrolling up to 156 patients
Decision to expand up to 120-130 patients now in 2021
11
PV: Phase 2 Data Support Advancement to Phase 3 Trial
* At least biweekly efgartigimod + corticosteroids @ 0.25-0.5mg/kg | 12 |
Cusatuzumab Strategy
Newly diagnosed elderly patients with AML unfit for intensive chemotherapy
Phase 2 CULMINATE Trial
Cusatuzumab + Azacitidine
Part 1: Dose selection
10 mg/kg | 20 mg/kg |
- 100 patients enrolled in dose selection
Trial to stop enrolling new patients
Topline data in early 2021
Phase 1b in Triple Combination
Cusatuzumab
+
azacitidine
+
venetoclax
Development plan strategy to
align with evolving AML
treatment landscape
Trial in Japan
continues to enroll
Higher-risk MDS trial remains on hold
ARGX-117: Sweeping Antibody Targeting C2
Unique Intervention in Complement Cascade
IgG IgM | Mannose sugar |
Showcase of Antibody Engineering Capabilities
Sweeping Antibody
Pipeline-in-a-Product
Potential
C1
MASPs MBL
qrs
C4
C2
C3 convertase
C3a C3 C3b
C5 convertase
C5a C5
Option
exercised
C5-C9for C2 (MAC)
Endosome
Lysosome
Cell
MMN
Lupus Nephritis
CAD Classical
GBSCIDP
Ischemia
AMR reperfusion IgAN
MGUS anti-MAG
MN LectinLectin HSCT
C4GN
14
Immunology Innovation Program
Accessing First-in-Class Targets by Collaborating with Leading Research Biologists
argenx | Academic Institutions & Biotechs |
Antibody Expertise | Disease Biology Expertise |
Co-creating immunology solutions: building beyond each individual contribution
ARGX-112 | ARGX-115 | ARGX-117 | ARGX-118 | ||||
Efgartigimod | Novel | ||||||
Up to | Up to | ARGX-114 | ARGX-116 | Cusatuzumab | Pipeline-in- | ||
Pipeline-in- | airway | ||||||
€120M and | $625M and | Profit share | Profit share | 50% U.S. | a-product | ||
a-product | inflammation | ||||||
royalties | royalties | potential | |||||
target | |||||||
ARGX-116 | |||||||
ARGX-114
8 assets from Immunology Innovation Program have delivered value to argenx
15
Preparing to Bring Efgartigimod to Patients in 2021
Reaching patients, physicians, payors in COVID-19 environment
Supply Chain Readiness
- Global manufacturing scale/flexibility
- Building inventory, 3PL selection
- Specialty pharmacy distribution
The Right Team in Place
- Commercial leads hired
- Field force of MRLs, TLLs, payor teams
- Sales force hires to start in 3Q20
BLA filing by end of 2020 + J-MAA filing in 1H21
Addressable MG Market: Patients Who Need Therapy Beyond Steroids
65,000 adult myasthenia gravis patients in
U.S.
55,000 patients have generalized
form of myasthenia gravis
20,000 patients require
more aggressive
treatment
Estimated Efgartigimod Addressable Market
85%
of people with MG progress* to generalized MG within 18 months
36%
of patients require treatment beyond steroids and ACIs
20,000
*Progression to gMG may be less with early immunosuppressive treatment
17
Hope for people living with myasthenia gravis
Eri Abdiel
Railroad inspector and father of six
Living with myasthenia gravis
"When I was younger, they told me I would never walk again … I was able to beat the odds on that, and I intend to beat the
odds on MG."
18
Half Year 2020 Financial Results
Six Months Ended | |||||||||||
June 30, | |||||||||||
(in thousands of € except for shares and EPS) | 2020 | 2019 | Variance | ||||||||
Revenue | € | 22,388 | € | 43,532 | € | (21,143) | |||||
Other operating income | 8,729 | 7,767 | 961 | ||||||||
Total operating income | 31,117 | 51,299 | (20,182) | ||||||||
Research and development expenses | (171,718) | (78,304) | (93,414) | ||||||||
Selling, general and administrative expenses | (61,644) | (27,462) | (34,181) | ||||||||
Total operating expenses | (233,362) | (105,767) | (127,595) | ||||||||
Change in fair value on non-current financial assets | 848 | - | 848 | ||||||||
Operating loss | € | (201,397) | € | (54,467) | € | (146,929) | |||||
Financial income/(expense) | (2,178) | 7,210 | (9,388) | ||||||||
Exchange gains/(losses) | 199 | 2,486 | (2,287) | ||||||||
Loss before taxes | € | (203,376) | € | (44,771) | € | (158,605) | |||||
Income tax (expense)/benefit | € | (2,261) | € | (350) | € | (1,911) | |||||
Loss for the year and total comprehensive loss | € | (205,637) | € | (45,121) | € | (160,516) | |||||
Net increase/(decrease) in cash, cash equivalents and current financial assets compared to | |||||||||||
year-end 2019 and 2018 | 596,977 | 1,368,229 | |||||||||
Cash, cash equivalents and current financial assets at the end of the period | 1,932,798 | 944,283 | |||||||||
19
Our Key Priorities
1 | File BLA by end of year |
2 | Commercial preparedness |
3 | Execute pipeline |
4 | Expand through Immunology |
Innovation Program | |
20
Thank You
visit argenx.com
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arGEN-X SE published this content on 30 July 2020 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 30 July 2020 12:40:12 UTC